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Targeting BTK with Ibrutinib in Relapsed or Refractory …
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Targeting BTK with Ibrutinib in Relapsed or Refractory …
Background Bruton's tyrosine kinase (BTK) is a mediator of the B-cell–receptor signaling pathway implicated in the pathogenesis of B-cell cancers. In a phase 1 study, ibrutinib, a BTK inhibitor, showed antitumor activity in several types of non-Hodgkin's lymphoma, including mantle-cell lymphoma.
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